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Peptides competing with peptides from GTPase-activating protein (GAP) and diagnostic and therapeutic use thereof
Peptides competing with peptides from GTPase-activating protein (GAP) and diagnostic and therapeutic use thereof
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机译:与来自GTPase激活蛋白(GAP)的肽竞争的肽及其诊断和治疗用途
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摘要
Peptides, that inhibit GAP stimulated ras p21 hydrolysis of GTP; peptides that mediate dissociation of GDP from ras p21-GTP complex; and antibodies to the peptides are described. These peptides are useful as cancer diagnostics and therapeutics, particularly to detect cancer cells with an over expression of normal or oncogenic ras p21 protein and to treat cancer caused by ras oncogene. Methods for assaying products of oncogenes using the described peptides and antibodies are also disclosed. Method for treating cancer caused by ras oncogenes is also disclosed. Prefered peptides are (Thr)-Met-Arg-Thr-Arg-Val-Val-Ser-Gly-Phe-Val-Phe-Lev-Arg-Lev-Ile-Cgs.
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