IN VIVO ASSAYS FOR INHIBITORS OF IgE MEDIATED ALLERGIC RESPONSES

摘要

In vivo assays for inhibitors of human allergic responses employ humanized transgenic mice in which at least one human gene encoding a chain of the Fc⊂RI receptor, replaces expression of its murine homologue. These assays are particularly useful for detecting inhibitors of IgE-mediated allergic responses.