SUBSTITUTED PYRIMIDINES FOR CONTROL OR DIABETIC COMPLICATIONS FOR DIABETIC COMPLICATIONS

摘要

The present invention relates to the use of a pyrimidine derivative of the general formula (I) below to inhibit sorbitol dehydrogenase, decrease fructose content and reduce or prevent diabetic neuropathy, diabetic retinopathy, diabetic nephropathy or diabetic nephropathy Or diabetic macroangiopathy, and pharmaceutical compositions of such derivatives.;Wherein R^One, R², R³, R⁴And R⁵Are as defined above.;The present invention also relates to novel substituted pyrimidines of the above general formula. The present invention also relates to a pharmaceutical composition comprising a co-drug precursor and an aldose reductase inhibiting compound of the compound of formula (I) and a compound of formula (I) and an aldose reductase inhibitor.