CETP Inhibitor Polypeptides, Antibodies to the Synthetic Polypeptides, and Prophylactic and Therapeutic Treatments of Atherosclerosis (CETP Inhibitor Polypeptides, Antibodies against the Synthetic Polypeptide and Prophylactic and Therapeutic AntiAtheroselerosis Treatments)

摘要

Polypeptides and their analogs inhibit cholesteryl ester transfer protein (CETP). An anti-atherosclerotic composition comprises an anti-atherosclerotic effective amount of a polypeptide and a pharmaceutically acceptable carrier. An anti-atherosclerotic kits kit comprising at least one unit of a composition containing a polypeptide in a separate sterile container. One syringe and one needle. The antibody is specific for the N-terminal fragment of 1-36 amino acids of the polypeptide of the invention, the Bibi CETP 4 kD polypeptide inhibitor, Apo CI, modified apo AI (MW: 31 kD) or modified apoE (MW: 41 kD) It is enemy. A method of preventing atherosclerosis in a mammal susceptible to atherosclerosis and administering a therapeutically effective amount of the polypeptide of the present invention comprising administering to a mammal a prophylactically effective amount of a polypeptide of the invention, A method for the treatment of atherosclerosis is provided.