METHOD OF SYNTHESIS OF METHYLENE-BIS-ANTHRANILIC ACID

摘要

FIELD: organic chemistry. SUBSTANCE: product: methylene-bis-anthranilic acid, empirical formual is C₁₄H₁₅N₂O₂,, m. p. is 241-242 C. Reagent 1: anthranilic acid. Reagent 2: formaldehyde. Reaction conditions: rearrangement of formed N N′-methylene-bis-anthranilic acid in aqueous hydrochloride solution at 50-75 C, crystallization of methylene-bis-anthranilic acid chlorohydrate, treatment with ammonia and acetic acid in aqueous medium. EFFECT: improved method of synthesis. 2 tbl