2-Halo-1,25-dihydroxycholecalciferols, pharmaceutical compositions, use as medicaments and process for the preparation of the cholecalciferols

摘要

2-Halo-1,25-dihydroxycholecalciferols, of the formula I IMAGE wherein X = chlorine or bromine and R1 = hydrogen or C1-C9-alkanoyl or benzoyl, and processes for their preparation. In addition to their vitamin D activity, the compounds have proliferation-inhibiting and cell-differentiating actions, that with respect to the cell differentiation being strongly dissociated compared with the hypercalcaemic action. The compounds are suitable for the preparation of medicaments.