1-PHENYL-1,2-ETHANEDIOL DERIVATIVE OR ITS SALT AS ACTION POTENTIATOR FOR NERVE GROWTH FACTOR

摘要

PURPOSE: To obtain the subject potentiator containing a phenyl-ethanediol derivative (salt) having a specific structure, manifesting the protentiating effect on the action of a nerve growth factor and useful as a therapeutic agent for Alzheimer-type dementia, etc. ;CONSTITUTION: The potentiator contains a 1-phenyl-1,2-ethanediol derivative or its salt of the formula (R¹ is phenyl; R² is H, a hydroxyl protecting group, etc.; R³ is H or a lower alkyl; R⁴, R⁵ are each H or a lower alkyl; R⁶ is amino, ammonia, etc.; (n) is 0-6). The compound of the formula or its salt can be administered orally or parenterally, and in the case of oral administration, it is preferable to be administered usually 0.01-500mg daily for an adult by dividing 1-several times.;COPYRIGHT: (C)1996,JPO