HIGHLY BIOCHEMICALLY ACTIVE BICYCLIC AROMATIC COMPOUND AND COMPOSITION CONTAINING SAME AND USED FOR MEDICINE AND COSMETIC

摘要

Bicyclic aromatic derivs. of formula (I) and their salts and optical and geometric isomers are new. R1 = H, Me, CH2OR6, OR8, COR10 or SOpR12; provided that R1 = OR8 only when R2+R4 form a fused benzene ring; R2 = H, lower alkyl, OH, OR7, OCOR7, amino or NHCOR7; R3 = H or lower alkyl; or R2+R3 = a bond; R4 = H, 1-20C alkyl, OH, OR7 or OCOR7; or R2+R4 forms a fused benzene ring; R5 = H, halo, lower alkyl, NO2, OH, OR7, OCOR7 or NR13R14; X = O, SOt or NR12; Y, Z = CR13R14, O or SOt; provided that not both are SOt or O; R6 = H, lower alkyl or COR7; R7 = lower alkyl; R8 = H, lower alkyl or (CH2)m(CO)nR9; R9 = lower alkyl or heterocyclyl; R10 = H, lower alkyl, OR11 or NR'R''; R11 = H, 1-20C alkyl, alkenyl, mono- or polyhydroxy-alkyl, opt. substd. aryl, opt. substd. aralkyl or a sugar, aminoacid or peptide gp.; R12 = H or lower alkyl; R13, R14 = H or lower alkyl; m = 1-3; n = 0-1; p = 0-3; t = 0-2; R', R'' = H, lower alkyl, mono- or polyhydroxy-alkyl, opt. substd. aryl or an aminoacid or sugar gp.; or NR'R'' = heterocycle; alkyl gps. contain 1-20C; lower = 1-12C.