In the blood clotting Characteristic protein the unique antibody and the native protein the proteolysis Characteristic cleavage product of those utilization and that protein in order to be isolated the blood clotting Characteristic constituent which is not included

摘要

A method for the generation of Ca++ independent antibodies against blood coagulation factors is described wherein an antibody selection strategy based upon small peptides comprising target sequences for limited proteolysis is employed. These antibodies which distinguish between intact and cleaved species of haemostatic protein provide novel tools for the isolation of intact haemostatic proteins.