Radiolabeled somatostatin-derived peptides and therapeutic applications of contrast

摘要

This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embodiments of such peptides labeled with technetium-99m (Tc-99m), as well as methods and kits for making, radiolabeling and using such peptides to image sites in a mammalian body. The invention also relatees to peptide derivatives and analogues of somatostantin labeled with rhenium-186 (186Re) and rhenium-188 (188Re), and methods and kits for making, radiolabeling and using such peptides therapeutically in a mammalian body.