Alteration human rizochi - mu, that ko - do gene and alteration human rizochi which are done - production manner null

摘要

PURPOSE:To obtain a modified human lysozyme which has salt concentration dependency and hydrogen ion concentration dependency different from those of natural lysozyme and can be used over a wide range of application such as bactericidal, preservative and medicines, by substituting at least one of amino acid in the natural human lysozyme with another amino acid. CONSTITUTION:For example, in the amino acid sequence of natural human lysozyme, the valine at the 74th is substituted with arginine, the arginine at the 41st, with glutamine, the valine and glutamine at the 74 and 126th, with arginines, or the arginines at the 41 and 101st, with glutamine and serine, respectively, to give the subject modified lysozyme. The number of charged amino acid residues on the molecular surface of the lysozyme increases or decreases.