Preparation of fluorophenols fluorohalophenols n-acylfluoroanilines and n-acylfluorohaloanilines and the novel fluorinating agent n-fluoro (trichloromethyl) pyridinium salt

摘要

Chloro and bromophenols and N-acylanilines are fluorinated in an ortho or para position with an N-fluoropyridinium salt to obtain fluorohalophenols and N-acylfluorohaloanilines, which can be further converted to fluorophenols and N-acylfluoroanilines by reduction. Thus, o- fluorophenol is obtained by fluorination of p-bromophenol with 2-chloro- 6- (trichloromethyl)-pyridinium fluoroborate and reduction of the product obtained with sodium formate and a palladium catalyst. N-fluoropyridinium salts having trichloromethyl substituents are disclosed.