OLIGONUCLEOTIDE INHIBITORS OF CYTOKINE PRODUCTION AND TUMORS RESPONSIVE TO CYTOKINES

摘要

A method for inhibiting cytokine production in cells, TNF-α protein production in cells and growth of TNF-α responsive cells is provided. The method includes the step of administering a therapeutic dose of an oligonucleotide. The oligonucleotide has a composition of guanosine sufficient to produce a three-dimensional structure stabilized by guanosine tetrads or has a composition of at least two runs of at least two contiguous guanosines. In other variations of the method, the composition of guanosine and thymidine is at least 70 %. Also disclosed are specific oligonucleotides useful in inhibition of TNF-α.