LIPOSOME COMPOSITION AND METHOD FOR ADMINISTERING LIPOSOME-LOADABLE DRUGS

摘要

A liposome composition and method of use in administering a compound having a reactive hydroxyl group to a selected in vivo site are disclosed. The composition includes a suspension of liposomes having an inside/outside pH gradient, and a conjugate of the compound with an adduct effective to maintain the compound in liposome-encapsulated form in response to the pH gradient.