A METHOD OF PREVENTING COLON CANCER WITH VITAMIN D3 ANALOGUES

摘要

It is provided a method for reducing the incidence of colon cancer by administering a nutrient supplement. The method comprises administering to a subject an effective amount of a non-calcemic analogue of vitamin D3 prior to and subsequent to the initiation of tumorigenesis. The present studies demonstrate that dietary supplementation with one such analogue, 1α,25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, can inhibit the development of colonic tumors in mammals. Moreover, this synthetic analogue of 1α,25(OH)2D3 appears to be well-tolerated by the animals, and does not induce hypercalcemia or alterations in the serum levels of phosphorus, 25(OH)D3, or 1,25(OH)2D3.