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IN VITRO DIFFERENTIATION OF CD34+ PROGENITOR CELLS INTO T LYMPHOCYTES
IN VITRO DIFFERENTIATION OF CD34+ PROGENITOR CELLS INTO T LYMPHOCYTES
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机译:CD34 +祖细胞体外分化为T淋巴细胞
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摘要
The invention involves a method for the in vitro T cell production. A monolayer of non-human primate thymic stromal cells are cocultured in vitro with primate hematopoietic T cell progenitor cells. This results in the differentiation and growth of mature T cells. The T cells may be isolated at any sequential stage of differentiation and further expanded by coculture with a mitogenic agent. The T cells also may be genetically altered at any stage of the process. The effect of agents on the growth and differentiation of T cells may be measured by comparing a coculture containing the agent with a control coculture and comparing the differentiation or growth of the T cells progenitor cells in the test culture with the control culture. Kits and novel populations of T cells are provided.
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