6-(2-(Substituted-Pyrrol-1-yl) alkyl pyran-2-one, which is a cholesterol synthesis inhibitor, Alkyl Pyran-2-One Inhibitors of Cholesterol Synthesis)

摘要

The invention -[2-(substituted pyrrol-1-yl) alkyl] pyran-2-one by a novel synthetic method which converts 7 steps of metallized N, N-disubstituted acetamide rolls to the desired product, In particular, (2R-trans-5-4-fluorophenyl-2-(1-methylethyl) N, 4-diphenyl-1-[2-(tetrahydro-Pyran-2-yl) ethyl]-1H-pyrrole-3-carboxamide, other fused intermediates used in the method, and prodrugs and pharmaceuticals thereof, which are converted in vivo to the treatment of dyslipidemia and cholesterol /RTI