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Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
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机译:使用聚氮杂配体的金属配合物修饰DNA和寡核苷酸
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摘要
A process is provided for oxidatively modifying nucleic acids containing a target nucleotide. The nucleic acid is contacted with a polyaza metal complex in the presence of an oxidizing agent so that the nucleic acid is modified at or near the target nucleotide. Also provided are a kit for carrying out the process and a method for treating neoplastic growth by administering to a subject having neoplastic growth, an effective amount of a polyaza metal complex which is capable of modifying DNA.
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