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Monoclonal antibody recognizing a surface molecule on a subset of antigen- stimulated T cells and on certain malignancies of T and B cell origin
Monoclonal antibody recognizing a surface molecule on a subset of antigen- stimulated T cells and on certain malignancies of T and B cell origin
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机译:单克隆抗体可识别抗原刺激的T细胞子集以及T和B细胞起源的某些恶性肿瘤上的表面分子
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摘要
This invention provides an IL-6 dependent B-cell lymphoma cell line designated DS-1 deposited with the American Type Culture Collection, wherein the cell line is reactive with a monoclonal antibody produced by a hybridoma cell line designated 10D2F6 deposited with the American Type Culture Collection. The invention also provides a purified antigen reactive with a monoclonal antibody produced by 10D2F6. The antigen also exists on DS-1. Also provided is a method of detecting the presence of an antigen-stimulated T-cell comprising detecting the presence of the antigen on a lymphocyte. In addition, the invention provides a method of detecting the presence of a neoplastic cell comprising detecting the presence of the antigen on a cell which is not normal a T-cell.
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