MEDICINAL COMPOSITION CONTAINING CARBAMOYLMETHYLUREA DERIVATIVE AND INTERMEDIATE FOR PRODUCING CARBAMOYLMETHYLUREA DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To obtain a pharmaceutical preparation, containing a carbamoylmethylurea derivative having a strong affinity for a gastrin receptor and/or a central cholecystokinin receptor and useful as a therapeutic agent for gastric or duodenal ulcer, etc. ;SOLUTION: This pharmaceutical preparation comprises a compound of formula I (R₁ is H or a lower alkyl; R₂ is a lower alkoxy, a lower alkylamino, etc.; R₃ is phenyl; R₄ is phenyl, a cycloalkyl, an alkyl or a heterocyclic ring) or its pharmaceutically permissible salt. e.g. 2-[(tert- butoxycarbonylmethyl)-[3-(m-(carboxyphenyl) ureidomethylcarbonyl]]aminobenzophenone. The compound of formula I is obtained by reacting a compound of formula II (R₉ is H or a carboxy-protecting group) with carbonyldiimidazole, reacting the resultant product with a compound of formula III (R₁₀ is the same as R₉) and using the prepared urea type compound of formula IV and a 2-substituted aniline derivative as starting raw materials.;COPYRIGHT: (C)1997,JPO