ORAL DOSAGE-FORMS CONTAINING A 'beta'-LACTAM ANTIBIOTIC.

摘要

A granulate, containing at least 50 wt.percent of a water soluble 'beta'-lactam antibiotic, is provided. A process to prepare a granulate containing such 'beta'-lactam antibiotic comprises moistening components making up the granulate with an aqueous solution containing no substantial amount of a wet granulation binding agent. Oral dosage-forms, which contain the said antibiotic in a granular form, a cellulose product and a disintegrant and which quickly disperse when placed in an aqueous environment, are disclosed, as well as a method for the preparation of the dosage-forms.