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somatotropiner med alterneringar i alfahelixregionen 1 och andra mutationer kombinationer med.
somatotropiner med alterneringar i alfahelixregionen 1 och andra mutationer kombinationer med.
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机译:生长激素在α螺旋区1和其他突变组合中具有交替变化。
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摘要
The present invention relates to somatotropin analogues with amino acid changes in the alpha-helix 1 regions of said somatotropins, alone or in combination with mutations in the alpha-helix 3 and/or alpha-helix 2 regions, plus combinations with other changes to the native amino acid sequence of somatotropins. The resulting analogues are stable for formulation in sustained release formulations, while maintaining biological activity. Further, methods for conducting site-directed mutagenesis on DNA encoding proteins and/or polypeptide also are provided.
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