CALIXPYRROLES, CALIXPYRIDINOPYRROLES AND CALIXPYRIDINES

摘要

The present invention provides calixpyrrole, calixpyridinopyrrole, andcalixpyridine macrocycles, having 4, 5, 6, 7, or 8 heterocyclic rings, as wellas syntheses, derivatives, conjugates, multimers, and solid supports thereof.Such macrocycles have proved to be effective and selective ion- and neutralmolecule-binding agents forming supramolecular ensembles, and ion- and neutralmolecule-separation agents. The macrocycles are fully meso-non-hydrogen-substituted porphyrinogens, a few molecules of which were previously known butnot recognized as possessing anion- or molecule-binding properties. Thebinding mode is noncovalent, primarily that of hydrogen-bonding, therebyproviding a new mode for liquid chromatography, that of Hydrogen BondingLiquid Chromatography. Further useful applications of the macrocycles providedherein include environmental remediation by removal of undesired ions orneutral molecules, and removal of phosphate for kidney dialysis.