NOVEL INTERMEDIATES FOR TAXAN HEMISYNTHESIS, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE GENERAL SYNTHESIS OF TAXANES

摘要

The present invention relates to new intermediaries for the hemisynthesis of taxanes and their preparation processes. It relates particularly to derivatives of oxazolidines or oxazolidinones, as well as to new derivatives of baccatine III. The general process for the synthesis of taxanes according to the invention enables to obtain a product such as PACLITAXELTM in only five steps from products available in the market, compared to nine steps in general, for processes of the prior art.