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AUXILIARY AGENT FOR DIRECT TABLETING, TABLET COMPRISING THE SAME AUXILIARY AGENT AND PRODUCTION OF TABLET

机译:直接制片的辅助剂,包括相同的辅助剂和片剂生产的片剂

摘要

PROBLEM TO BE SOLVED: To prepare an auxiliary agent for direct tableting, capable of rapidly disintegrating at a low dusting ratio and having a high uptake capacity for a hardly tableted ingredient in spite of a good fluidity and a good binding power possessed thereby in order to form a tablet having a moderate hardness. SOLUTION: This auxiliary agent for direct tableting (i.e., the one without containing an active substance) comprises the following mixture: (A) 75-98wt.%, preferably 89-93wt.% powdery cellulose suitable for tableting with (B) 1-15wt.%, preferably 2-6wt.% soluble polyvinylpyrrolidone and (C) 0.5-10wt.%, preferably 2-5wt.% insoluble polyvinylpyrrolidone.
机译:解决的问题:制备用于直接压片的助剂,尽管其具有良好的流动性和良好的结合力,但它能够以低粉尘比迅速崩解并且对难于压片的成分具有高吸收能力。形成具有中等硬度的片剂。解决方案:这种直接压片助剂(即不含活性物质的助剂)包含以下混合物:(A)75-98wt。%,优选89-93wt。%的粉状纤维素,适合用(B)1- 15重量%,优选2-6重量%的可溶性聚乙烯基吡咯烷酮和(C)0.5-10重量%,优选2-5重量%的不溶性聚乙烯基吡咯烷酮。

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