Polypeptides for Inducing Protective Immunity against tuberculosis DNA Molecule that encodes a expression vector, host Cell, a Pharmaceutical composition, a vaccine,A fusion protein, and a method for Detecting TB Diagnostic KIT.

摘要

A polypeptide is characterised in that it comprises a portion of an immunogenic Antigen soluble M.Tuberculosis, or a variant of that antigen quedifiere only Conservative substitutions and / or modifications.In which the Antigen is a sequence of N - terminal selected from the group consisting of: (a) ASP Pro Ala - ASP Val Val ile ASN THR THR CYS ASN Tyr Gly - Gln Val Val ala ala Leu (sec.id.(b) nu00b0120) - Val Glu ala Gly Leu met be - ala Gly THR Leu Pro Ala pro ser (sec.id. Nu00b0121) (c) met ala ala Lys pro ARG Gly ASP THR Gly pro - Leu Glu ala Lys Glu Gly ARG (sec. Id.(d) nu00b0122) Tyr Tyr TRP Gly GYS - Pro - Pro GLN ASP PHE Pro Ala pro Gly TRP (sec.id. Selective (e) ASP ile Glu Gly ser THR ser Glu ASP GLN GLN XAA ala Val (sec.id.(f) nu00b0124) ala Glu Glu ile THR - - - - - - - Xaa XAA Glu ile Val Pro (sec.id. Nu00b0125) (g) - Pro Glu ASP Pro Ala pro Pro Val pro THR THR ala ala be pro Pro ser (sec.ID no. 16 (H)) | ala Lys - Pro - Thr - Tyr - NAA Glu Glu Leu Lys Gly THR Gly - ASP THR (sec.id.(i) no 127) ASP Pro Ala pro ala - ASP Val pro THR ala GLN THR Leu - Leu - Leu - - - - - - be ASN Leu ASP Pro Ala ASN PHE ala Val - - - - ASN (sec.id.No. 128 (j) - ASP ser XAA Glu Lys - ala thr ile Lys Val THR ala - ASP - ser (sec.id. Nu00b0134) where XAA can be any amino acid.These polypeptides can be formulated into Pharmaceutical compositions and / or Vaccines for Immunization against