THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES AND THEIR DERIVATIVES WITH OPEN RING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF

摘要

The present invention relates to compounds of formula (I) wherein R 1 is n. and R.sup.2.n. is hydrogen or alkyl; and R.sup.2.n. together form a group - (CH.sub.2.n), sub.k.n.-, R.sup.3.n. is hydrogen, alkyl, alkoxy, halogen or hydroxyl, A and B are hydrogen, alkyl, aralkyl. carboxyacyl optionally substituted with an aryl group, and carbamoyl or A and B together form a group C = O, C = S, -C (= O) -C (= O) -, -CH.sub. 2.nC (= O) -, - CH.sub.2.sub.2.sub.2-, -SO.sub.2- or -CH.sub.2. X is a group of formula (III) wherein W is aryl or heterocycle; is a single bond, an oxygen atom, a sulfur atom, or an N.sub.4 atom, where R.sup.4 is n. is hydrogen, alkyl, arylalkyl, or aryl and m is 0 or an integer, Y is a group of formula IV wherein Y is 1, n. is a single bond, an oxygen or sulfur atom and n is an integer, Z is a group of formula V, VI, VII, VIII, IX or X wherein R 5 is n. is hydrogen, carboxyalkyl, alkanoyloxyalkyl, alkanoyloxyalkyl substitution