FremgangsmÕte og formuleringer til Õ forhindre og/eller behandle alle infeksjoner (spesielt seksuelt overf°rte sykdommer inkludert HIV), inflammatoriske, neoplastiske eller andre typer sykdommer i slimhinner og/eller hud

摘要

PCT No. PCT/CA97/00319 Sec. 371 Date Jan. 13, 1999 Sec. 102(e) Date Jan. 13, 1999 PCT Filed May 9, 1997 PCT Pub. No. WO97/42962 PCT Pub. Date Nov. 20, 1997This invention relates to formulations comprising film-forming components capable of forming per se a physical barrier to pathogens. Thermoreversible gels such as poloxamers are particularly preferred for that use. The film-forming formulations may further comprise microbicides, spermicides or any other drug, which choice is guided by the pathogen, organism or the disease to be inactivated or treated. The formulations are therefore efficient as a physical, and optionally, as a chemical or pharmacological barrier as well as usable as a sustained drug-release system at the locus of administration. A part of the drug may also be entrapped in liposomes or other drug carriers. These formulations are intended for use in the prevention of sexually transmitted diseases, as well as in the treatment of infections, cancer, inflammation or any disease or state which requires a pharmacological treatment. Formulations are applicable to mucosae, skin and eye, for example.