MONOCLONAL ANTIBODIES AND BINDING PROTEINS WHICH BIND TO HUMAN FAS ANTIGEN (NERVE GROWTH FACTOR/TUMOUR NECROSIS FACTOR RECEPTOR TYPE)

摘要

The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of stimulating T cell proliferation, inhibiting binding of anti-Fas CH-11 monoclonal antibody to cells expressing Fas antigen, blocking anti-Fas CH-11 monoclonal antibody-mediated lysis of cells, and blocking Fas ligand-mediated lysis of cells. The invention also provides for therapeutic compositions comprising the monoclonal antibodies.