GEM BI-SUBSTITUTED AZACYCLIC TACHYKININ ANTAGONISTS

摘要

PCT No. PCT/GB95/00057 Sec. 371 Date Jul. 11, 1996 Sec. 102(e) Date Jul. 11, 1996 PCT Filed Jan. 12, 1995 PCT Pub. No. WO95/19344 PCT Pub. Date Jul. 20, 1995The present invention is directed to certain compounds represented by structural formula I: t thereof wherein R1, R2, R3, R4, R5, R6, R7, A1, A2, X, m and n are defined herein. The compounds of this invention are tachykinin receptor antagonists and are of particular use in the treatment of pain, inflammation, migraine and emesis.