MONOCLONAL ANTIBODY WHICH DISTINGUISHES HELPER INDUCER AND SUPPRESSOR INDUCER CD4+ LYMPHOCYTES

摘要

A monoclonal antibody which binds preferentially to a subset of the human CD4+ lymphocyte population whereby topositively and precisely distinguish between helper-inducer and supressor-inducer cells in the CD4+ cell population. Themonoclonal antibody recognizes a novel antigen on the CD4+ lymphocytes by means of which it can bind CD4+ cells which expressthe antigen on the surface of CD4+ cells. The CD4+ subset cell population to which this antibody preferentially binds is theCD4+ helper-inducer population. This selectivity of the monoclonal antibody enables cell sorting, diagnostic and possibletherapeutic applications thereof to be realized. The monoclonal antibody also reacts with CD8 cells, B cells and macrophages.