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Expression of NTRK1-derived oncogenes in PC12 pheochromocytoma cells and use thereof for the screening of anti-tyrosine kinase compounds
Expression of NTRK1-derived oncogenes in PC12 pheochromocytoma cells and use thereof for the screening of anti-tyrosine kinase compounds
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机译:NTRK1致癌基因在PC12嗜铬细胞瘤细胞中的表达及其在筛选抗酪氨酸激酶化合物中的用途
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摘要
The present invention provides an in vitro cell culture system, based on neuronal cells comprising oncogenic derivatives of the NGF-receptor gene NTRK1, and exhibiting NGF-independent neuronal differentiation closely resembling NGF-induced cellular responses in normal cells, but differing from these responses by displaying cellular degeneration after prolonged culture periods. The present invention furthermore provides eukaryotic expression vectors containing cDNAs coding for the NTRK1-derived oncoprotein TRK-T1, and a method to obtain said neuronal cells by transformation with eukaryotic expression vectors coding for oncogenic derivatives of NTRK1.
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