Manganese complexes with nitrogen-containing macrocyclic ligands, effective as superoxide dismutase catalysts.

摘要

The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: CHEM wherein R, R min , R1, R min 1, R2, R min 2, R3, R min 3, R4, R min 4, R5, R min 5, R6, R min 6, R7, R min 7, R8, R min 8, R9, and R min 9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.