Antisense oligonucleotides inhibiting human bcl-2 gene expression

摘要

The present invention provides novel antisense oligodeoxynucleotides which are useful in inhibiting lymphoma or leukemia cells. The subject oligodeoxynucleotides are complementary to a strategic site in the mRNA sense strand to the human bcl-2 gene. Such oligodeoxynucleotide are provided either in their native state or as a derivative such as the phosphorothioate. In the preferred embodiments, these antisense oligodeoxynucleotide straddle the predicted translation- initiation site of the mRNA coding strand, the splice donor region, the splice acceptor region of the mRNA coding strand, or the 5'-cap region for the human bcl- 2 gene.