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Nucleic acid encoding a novel homeobox factor which stimulates insulin expression in pancreatic islet cells
Nucleic acid encoding a novel homeobox factor which stimulates insulin expression in pancreatic islet cells
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机译:编码新的同源盒因子的核酸,其刺激胰岛细胞中胰岛素的表达
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摘要
In accordance with the present invention, there are provided novel homeobox-type pancreatic islet transcription factor proteins useful to bind to tissue-specific elements (TSEs) within a pancreatic islet hormone gene promoter and modulate hormone gene expression both in vivo and in vitro. Nucleic acid sequences encoding such transcription factor proteins and assays employing same are also disclosed. The invention transcription factor proteins can be employed in a variety of ways, for example, to modulate RNA transcription, for production of antibodies thereto, in therapeutic compositions and methods employing such proteins and/or antibodies.
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