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Antibodies specifically immunoreactive with human brain Ca.sup.2+ /calmodulin cyclic nucleotide phosphodiesterase
Antibodies specifically immunoreactive with human brain Ca.sup.2+ /calmodulin cyclic nucleotide phosphodiesterase
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机译:与人脑Ca 2+ /钙调蛋白环核苷酸磷酸二酯酶特异性免疫反应的抗体
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摘要
The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
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