Asymmetrical synthetic method and the N of S acyl derivative of 2 merukaputomechiru 3 phenyl propane acid (merukaputoashiru) utilization to amino acid derivative synthesis

摘要

(57) Abstract 2 - merukaputomechiru formula (i) - 3 - asymmetrical synthetic method of S-ashiru derivative of phenyl propane acid. a) restoring malonic ester V under existing of the hydride, it makes diol VI, b) mono acetate (VII R or VII S) makes respectively, oxidizes c) these mono acetate and acid (IXS or IXR) forms, d) chemical compound (IXS or IXR) saponifies and hydroxy acid (XS or XR) forms, e) hydroxy acid (XS or XR) merukaputo acid R₁ SH (XI) with the thio acylation does with the mitsunobu type reaction and the acid of desire (IR and IS) obtains. N- (merukaputoashiru) it is utilized in the synthesis amino acid derivative (ii).