INHIBITOR FOR DECOMPOSITION OF HYALURONIC ACID, AGENT FOR IMPROVING AND TREATING DISEASE CAUSING ABNORMAL DECOMPOSITION OF HYALURONIC ACID AND AGENT FOR PREVENTING GINGIVITIS AND AGENT FOR PREVENTING DRY SKIN OR ROUGH SKIN

摘要

PROBLEM TO BE SOLVED: To obtain an inhibitor for decomposition of hyaluronic acid, acting on a cell which exists in human binding tissue and inhibiting decomposition of hyaluronic acid and useful as an agent for improving and treating diseases causing abnormal decomposition of hyaluronic acid such as rheumatism, osteoarthritis and malignant tumor by including heparin. ;SOLUTION: This inhibitor contains heparin and/or its salt extracted according to ordinary method from intestine or the like of pig or the like, preferably in an amount of 0.001-5 g based on 100 g total amount of medicine. Daily doses of the compound is preferably 1-10 g as total amount of heparin and its salt in the case of oral administration and preferably 0.1-5 g in the case of parenteral administration. The medicine is useful as an agent for improving and treating diseases causing abnormal decomposition of hyaluronic acid, e.g. hepatitis, gingivitis and fibrosis.;COPYRIGHT: (C)1999,JPO