Method for producing 5'-inosinic acid by fermentation method

摘要

PURPOSE:To obtain the subject compound, utilizable as a seasoning and useful in the field of food industry by culturing a specific microorganism, belonging to the genus Corynebacterium and having tolerance to L-proline-antagonistic substance in a culture medium. CONSTITUTION:A microorganism [e.g. a variant strain obtained by subjecting Corynebacterium Ammoniagenes KY13184 (FERM P-3790) as a parent strain to varying treatment, such as by N-methyl-N'-nitro-N-nitrosoguanidine, ultraviolet rays or X-rays], belonging to the genus Corynebacterium and having tolerance to L-proline-antagonistic substance is cultured in a culture medium to produce and accumulate 5'-inosinic acid in the resultant culture and collect the resultant 5'-inosinic acid.