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In the form of small molecules are inhibitors of rotamase enzyme activity

机译:小分子形式是旋转酶活性的抑制剂

摘要

This application relates to 3-phenyl-1-prbpyl(2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate. It further relates to a method of preparing such a compound comprising the step of reacting (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidinecarboxylic acid with 3-phenyl-1-propanol and dicyclohexylcarbodiimide. Finally, the application relates to the intermediate compound (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidinecarboxylic acid which may be used to produce 3-phenyl-1-propyl(2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate. 3-phenyl-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate functions as a rotamase enzyme inhibitor and is therefore useful as a component in pharmaceutical compositions, in particular for promoting neuronal growth and regeneration and for treating neurological disorders.
机译:本申请涉及3-苯基-1-丙基(2S)-1-(3,3-二甲基-1,2-二氧戊基)-2-吡咯烷羧酸酯。本发明还涉及一种制备这种化合物的方法,该方法包括使(2S)-1-(1,2-二氧代-3,3-二甲基戊基)-2-吡咯烷羧酸与3-苯基-1-丙醇和二环己基碳二亚胺反应的步骤。 。最后,本申请涉及可用于生产3-苯基-1-丙基(2S)-的中间体化合物(2S)-1-(1,2-二氧代-3,3-二甲基戊基)-2-吡咯烷羧酸。 1-(3,3-二甲基-1,2-二氧戊基)-2-吡咯烷羧酸酯。 3-苯基-1-丙基(2S)-1-(3,3-二甲基-1,2-二氧戊基)-2-吡咯烷羧酸酯起旋转酶抑制剂的作用,因此可用作药物组合物中的组分,特别是用于促进神经元的生长和再生,并治疗神经系统疾病。

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