7-BROMO- AND 7,7 DIBROMO-CEPHAM AND CEPHEM DERIVATIVES

摘要

The object of the present invention relates to novel 7-bromo- and 7,7-dibromo-cepham and 7-bromo- and 7,7-dibromo-cepham derivates of general formula I CHEM wherein the radicals have the meanings R1 is hydrogen or bromine, R2 is hydrogen or bromine, R3 is bromine, R4 is methyl, hydroxy, R5 is -OR6 or -NR7R8, wherein R6, R7 and R8 are hydrogen, alkyl, alkylaryl, n = 0, 1, 2, and of general formula II CHEM wherein the radicals have the meanings R1 is hydrogen or bromine, R2 is hydrogen or bromine, R3 is methyl, R4 is hydrogen, -COOR5 or CONR6R7, wherein R5, R6 and R7 are hydrogen, alkyl, alkylaryl, n = 0, 1, 2. According to the present invention novel compounds are potentially active as inhibitors of proteases, especially humen leukocyte elastases (HLE).