5- (PHENYL) -3- (4-PIPERIDINYL) -1,3,4-OXADIAZOLE-2 (3H) -ON DERIVATIVES USED AS 5-HT4 OR H3 RECEPTOR LIGANDS

摘要

PCT No. PCT/FR96/01730 Sec. 371 Date May 8, 1998 Sec. 102(e) Date May 8, 1998 PCT Filed Nov. 5, 1996 PCT Pub. No. WO97/17345 PCT Pub. Date May 15, 1997Compounds corresponding to the general formula (I) in which R1 represents a (C1-C4)alkyl or (C3-C7)cycloalkylmethyl group, X1 represents a hydrogen or halogen atom or a (C1-C4)alkoxy group or else OR1 and X1 together represent a group of formula -OCH2O-, -O(CH2)2-, -O(CH2)3-, -O(CH2)2O- or -O(CH2)3O-, X2 represents a hydrogen atom or an amino group, X3 represents a hydrogen or halogen atom, and R2 represents either a hydrogen atom or an optionally substituted (C1-C6) alkyl group or a phenyl (C1-C4) alkyl group which is optionally substituted on the phenyl ring or a phenyl (C2-C3) alkenyl group or a phenoxy (C2-C4) alkyl group or a cyclo (C3-C7) alkylmethyl group or a 2,3-dihydro-1H-inden-1-yl or 2,3-dihydro-1H-inden-2-yl group or a group of general formula -(CH2)nCO-Z in which n represents a number from 1 to 6 and Z represents a piperidin-1-yl or 4-(dimethylamino)piperidin-1-yl group. Application in therapeutics.