The invention relates to hBKb3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. The invention also relates to methods for utilizing hBKb3 polypeptides and polynucleotides in the design of protocols for the treatment of asthma, cerebral and cardiac and renal ischemias, brain and cardiac diseases, inflammation, pain, to mimic or antagonize effect of endogenous neurotransmitters and hormones, or to diagnose or treat any disorder related to abnormal expression of this protein, among others and diagnostic assays for such conditions.
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