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Vaccines for (chlamydia psittaci) infections

机译：衣原体（鹦鹉热衣原体）感染疫苗

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摘要

Vaccine compositions protective against Chlamydia psittaci infections in animals, including but not limited to humans and avian species, comprising an immunogenic amount of a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 are provided. Nucleic acid vectors for the expression of MOMP polypeptides and MOMP polypeptide fusion proteins are disclosed. Nucleic acid vectors encoding a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 useful for genetic, or "naked nucleic acid" vaccination are disclosed. Methods for preventing a Chlamydia psittaci infection in a subject using MOMP polypeptides, MOMP polypeptide-fusion proteins, or nucleic acid expression vectors are also provided.

机译：提供了对动物（包括但不限于人和禽类）的鹦鹉热衣原体感染具有保护作用的疫苗组合物，其包含免疫原性的鹦鹉热衣原体主要外膜蛋白（MOMP）多肽缺乏区域VD1和VD2。公开了用于表达MOMP多肽和MOMP多肽融合蛋白的核酸载体。公开了编码缺少热可食梭菌主要外膜蛋白（MOMP）多肽的区域的核酸载体的核酸载体，所述区域VD1和VD2可用于遗传或“裸核酸”疫苗接种。还提供了使用MOMP多肽，MOMP多肽融合蛋白或核酸表达载体在受试者中预防鹦鹉热衣原体感染的方法。

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公开/公告号AU9039398A

专利类型
公开/公告日1999-03-16

原文格式PDF
申请/专利权人 UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC.;
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申请/专利号AU19980090393
发明设计人 ABOLGASEM BAGHIAN;THOMAS N. TULLY JR.;KONSTANTIN G KOUSOULAS;VLADIMIR N. CHOULJENKO;
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申请日1998-08-28
分类号A61K38/00;A61K39/00;A61K39/02;A61K39/385;C12N15/00;C07K5/00;C07H21/04;
国家 AU
入库时间 2022-08-22 02:22:21

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1. Development of a Novel PmpD-N ELISA for Chlamydia psittaci Infection [J] . LIU Shan Shan, CHU Jun, ZHANG Qiang, 生物医学与环境科学（英文版） . 2016,第005期

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4. Expression of the Chlamydia psittaci major outer membrane protein in Escherichia coli: A model for translocation and vaccine development. [D] . Dascher, Christopher Carter. 1994

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