METHODS FOR THE SIMULTANEOUS IDENTIFICATION OF NOVEL BIOLOGICAL TARGETS AND LEAD STRUCTURES FOR DRUG DEVELOPMENT

摘要

The combinatorial screening assays and detection methods of the present invention encompass highly diversified libraries of compounds which act as fingerprints to allow for the identification of specific molecular differences existing between biological samples. The specific molecular differences identified by the combinatorial screening assay and detection methods of the present invention are potential targets for diagnosis and development therapeutics. The methods of the invention can be used in diagnostics, drug discovery, as well as genomics and proteomics. Figure (1) which is illustrative of the methods of the invention shows the interaction between molecular probes described in Table II and a human serum sample.