Pharmacological agent is identified in high production drug screening measurement, and the diagnosis or treatment to disease associated with the expression of a gene are useful. Method is related to combining the transcription factor of a label, nucleic acid, a candidate pharmacological agent and the receptor for being coupled to a cooperation base, is fixed on a solid substrate, such as a microtiter plate, filter or pearl. Nucleic acid have at least that be related to naturally for sequence specific be with transcription factor interaction required gene transcription management nucleotide sequence part. The combination of synthesis is incubated under situation, therefore receptor is bound to cooperation base, and still for the presence of the candidate pharmacological medicament, transcription factor is the nucleic acid that sequence is specifically bound to. Then cutting transcription factor removes or washes from solid substrate and label, detection sequence-particularly controlled transcription factor. The candidate agent deviation control that it includes the transcription factor for changing binding is incubated to incubate for label signal -- in general, binding division, and signal is reduced. In the preferred embodiment, entire processing is carried out by a computer controlled electric-machine driving machine people with an axial rotatable arm.
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