THERAPEUTIC COMPOSITIONS WITH CONTROLLED RELEASE OF MEDICAMENTS SUPPORTED ON CROSSLINKED POLYMERS AND COATED WITH POLYMER FILMS, AND THEIR PREPARATION PROCESS

摘要

Therapeutic compositions in which the release of a medicament containing a drug loaded in the form of particles of a crosslinked nonionic polymer that is insoluble but swellable in water is controlled using a method of swelling with a solution of the drug or by using a high energy co-pulverization method . Drug-loaded particles can be coated with a polymer film that can control the release of the drug to prolong release (greater than 24 hours) while maintaining high bioavailability.