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Treatment methods for disease using co-localized cells and Sertoli cells obtained from a cell line
Treatment methods for disease using co-localized cells and Sertoli cells obtained from a cell line
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机译:使用从细胞系获得的共定位细胞和支持细胞治疗疾病的方法
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摘要
A method of treating a disease is provided that results from a deficiency of a biological factor which comprises administering to a mammal Sertoli cells and cells that produce the biological factor. A method of treating diabetes mellitus is carried out by transplanting pancreatic islet of Langerhans cells in conjunction with Sertoli cells to create an immunologically privileged site. A method of creating an immunologically privileged site and providing cell stimulatory factors in a mammal for transplants is also carried out. A method of co- localizing islet cells with Sertoli cells and the use of the co- localized product for treating diabetes mellitus is further provided. Further described is a method of creating systemic tolerance to foreign antigens. A method of enhancing the viability, maturation, proliferation of functional capacity of cells in tissue culture is also provided. In addition, a pharmaceutical composition comprising Sertoli cells and cells that produce a biological factor is provided.
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