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DETECTING METHOD FOR RENAL DISEASE ND CONTROL METHOD FOR MORBIDITY OF RENAL DISEASE

机译:肾脏疾病的检测方法和疾病发病率的控制方法

摘要

PROBLEM TO BE SOLVED: To provide a method wherein a renal abnormality which cannot be detected by various inspection means with reference to a renal disease and which is generated before an early nephoropathy period an be detected precisely and by reducing the burden of a subject. SOLUTION: In an early detecting method for a renal disease, the concentration of a human lipokairine-type prostaglandin D synthetase in a humor sample collected from a subject is measured, and its measured value is compared with a reference value which is set on the basis of the measured value of a human lipokairin-type prostaglandin D synthetase in a humor sample collected from a healthy person. In this control method for the morbidity of a renal disease, the concentration of a human lipokairin-type prostaglandin D synthetase in a humor sample collected from a subsject is measured, and the filtration capability of a glomerulus is assessed on the basis of its measured value. Thereby, the control method can detect a renal abnormality more remarkably than creatinine, in bllod, or alubumin, in urine, which are used at present as an index of a reanl disease which has a lesion in a glomerulus such as a glomerulus nephritis, diabetic nephotopathy or the like.
机译:解决的问题:提供一种方法,其中可以通过参照肾脏疾病的各种检查手段检测不到并且在早期肾病期之前产生的肾脏异常,并且可以通过减轻受试者的负担来准确地检测出该肾脏异常。解决方案:在一种肾脏疾病的早期检测方法中,测量从受试者采集的体液样品中人脂蛋白碱型前列腺素D合成酶的浓度,并将其测量值与根据该标准设定的参考值进行比较人脂联蛋白型前列腺素D合成酶在从健康人收集的体液样品中的测量值的平均值。在这种用于控制肾脏疾病发病率的方法中,测量从受试者收集的体液样品中人脂联蛋白型前列腺素D合成酶的浓度,并根据其测量值评估肾小球的过滤能力。 。从而,该控制方法可以比尿液中的肌酸酐或阿鲁巴明中的肌酐更明显地检测出肾脏异常,尿液中的肾异常目前被用作肾小球疾病如肾小球性肾炎,糖尿病性肾小球病变的指标肾病或类似疾病。

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