首页> 外国专利> A compound of 3 - epi isolated Vitamin D3, a composition containing such a compound farmaceuitica, packagingMethods for treating a desordenrelacionado with abnormal activity of a cell sensitive to Vitamin D3, to reduce the activity of a cell of the skin hiperproliferativa, PA

A compound of 3 - epi isolated Vitamin D3, a composition containing such a compound farmaceuitica, packagingMethods for treating a desordenrelacionado with abnormal activity of a cell sensitive to Vitamin D3, to reduce the activity of a cell of the skin hiperproliferativa, PA

机译:3-epi分离的维生素D3的化合物,含有这种化合物的组合物,包装用于治疗对维生素D3敏感的细胞具有异常活性的去甲壳多糖的方法,以降低皮肤hiperproliferativa,PA的细胞的活性

摘要

3 - epi Vitamin D3 compounds with the orientation of the Substituent attached to the carbon in position 3 of the Ring of Vitamin D3 from inverted configuration (alpha beta) to a ().These compounds of 3 - epi were first identified as Vitamin D3 metabolites produced through a Tissue specific Metabolic Route,That catalyzes the 3 - beta - hydroxy epimerization of compounds of Vitamin D3.- epu00edmeras aislada3 forms of the compounds have been characterized and demonstrated vitaminad3 possessing improved Biological properties in comparacioncon counterparts isomericSuch as a hypercalcaemic activity reduced and greater stability in vivo.Devitamina D3 compounds can be used as substitutes of natural compounds and Synthetic Vitamin D3.
机译:3-epi维生素D3化合物,其取代基的方向与维生素D3环的3位碳连接,从反转构型(αbeta)到()。这些3-epi化合物首先被鉴定为维生素D3代谢产物通过组织特异性代谢途径产生,催化维生素D3化合物的3-β-羟基差向异构化。-epepedasas aislada3形式的化合物已被表征并证明,维生素ad3在比较对等异构体中具有改善的生物学特性,例如高钙血症Devitamina D3化合物可用作天然化合物和合成维生素D3的替代品。

著录项

  • 公开/公告号AR012714A1

    专利类型

  • 公开/公告日2000-11-08

    原文格式PDF

  • 申请/专利权人 F.HOFFMANN-LA ROCHE AG Y WOMEN;INFANTS HOSPITAL;

    申请/专利号AR1998P102289

  • 发明设计人

    申请日1998-05-18

  • 分类号C07C401/00;A61K31/59;

  • 国家 AR

  • 入库时间 2022-08-22 01:57:31

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